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What Should You Know About Microsoft Defender for Office 365? 

microsoft-defender-for-office-365
By Meghana
September 25, 2025

Defender for Office 365 is a powerful platform equipped with advanced threat protection capabilities. Microsoft Defender helps business users stay one step ahead of cyber adversaries, ensuring the safety of your data, employees, and your business reputation. Defender for Office 365 empowers your organisation by defending against phishing attacks, malware, and other security threats in real-time. It provides a robust defence that allows stakeholders to focus on what matters most – accelerating growth to drive the business forward.

Understanding Microsoft Defender in Detail: 

Microsoft Defender for Office 365 is a cloud-based email filtering application designed to protect the Microsoft 365 environment from threats such as phishing, business email compromise, ransomware, and zero-day malware. It extends protection beyond Exchange Online to Teams, OneDrive, and SharePoint.  It integrates seamlessly with Microsoft 365 subscriptions to render advanced security features to safeguard email, links, attachments, and collaboration tools. Here are more details: 

  • Safe Attachments protect against unknown malware and viruses by providing zero-day protection. It scans all messages and attachments without a recognisable virus/malware signature using machine learning and analysis techniques to detect malicious intent. 
  •  Safe Links proactively protects users from malicious URLs that lead to phishing sites, malware downloads, or other harmful destinations. The protection remains active every time a user clicks the link, dynamically blocking malicious links while allowing access to safe ones. 
  • Safe Documents leverages Microsoft Defender for Endpoint to scan documents and files opened in Protected View. It is available in Microsoft 365 E5 or Microsoft 365 E5 Security licenses. 
  • Anti-Phishing Policies Microsoft Defender for Office 365 includes advanced anti-phishing policies that help detect and block phishing attempts. These policies use machine learning models to analyse email content and sender behaviour to identify potential threats. 
  • Threat investigation and response solution allows security teams to identify, investigate, and remediate threats quickly. This includes automated investigation and response capabilities, which help reduce the efforts required to address security incidents. 

Get started with a Secure digital Workspace with Defender for Office 365

Here is a glimpse of security features offered by the Defender for Office suite, and the levels of protection provided:

Feature / Inclusion  MDO Plan 1  MDO Plan 2 
Included in  Microsoft 365 Business Premium  Office 365 E5, Office 365 A5, Microsoft 365 E5 
Add-on  Other Microsoft 365/Office 365 plans  Other Microsoft 365/Office 365 plans 
Core Protection  Protects against unsafe attachments, links, and phishing attempts  All Plan 1 features plus advanced protection and automation 
Safe Links   Time-of-click verification for links in emails and documents  Enhanced policies, real-time URL detonation 
Safe Attachments  Scans email attachments for malware  Advanced scanning with deep inspection 
Anti-Phishing Policies  Detects and blocks impersonation attempts  Advanced impersonation detection using AI/ML 
Automated Investigation & Response (AIR)  Not included  Automates threat investigation and remediation 
Attack Simulation Training  Not included  Built-in phishing and security awareness training simulations 
Best suited for  SMBs with Microsoft 365 Business Premium or those wanting baseline protection  Enterprises or regulated industries needing advanced threat protection, automation, and compliance 
Threat Trackers   Not included   Real-time threat intelligence and monitoring 
Quarantine & Reporting   User & admin quarantine access  Enhanced investigation, threat explorer, and reporting 

Note:

  • MDO Plans 1 and 2 are available as add-ons as needed. 
  • Default email protections for cloud mailboxes in all Microsoft 365 subscriptions with cloud mailboxes. 

All the Latest with Defender for Microsoft 365: 

Defender has just become smarter and easier for users, thanks to automated, real-time updates from the cloud and Microsoft 365 integration. It is now possible to report suspicious Microsoft Teams messages, in addition to emails, for enhanced protection across collaboration tools. New mail bombing detection helps block inbox floods, while AI-powered admin responses make investigations faster and more efficient. Defender also adds advanced BEC detection, IPv6 support, and quicker quarantine management—all designed to keep your business secure with less effort.

Feature   Details 
Endpoint protection and threat detection  Monitors devices 24/7 for viruses, spyware, ransomware, and other threats. 
Utilises machine learning and cloud analysis to prevent malware from spreading. Attack Surface Reduction (ASR) to block risky actions and unapproved software from running. 
Defends against zero-day threats and exploits targeting system weaknesses. 
Automated investigation and remediation  Quickly investigates and contains threats with minimal IT effort. 
Quarantines malicious files and rolls back changes caused by attacks without manual input. 
Advanced Threat and Vulnerability Management   Detects device and software weaknesses before hackers Helps fix the most critical issues first Look for missing patch updates 
Real-time alerts and monitoring   Detects unusual activities instantly and sends notifications Sets up custom alerts based on need and risk levels 
Ransomware   Stops file locking malware before data damage occurs Protects critical folders from unauthorised apps and users 
Device management   Manage devices from a single dashboard Isolate scan and wipe off data from stolen/missing devices Protect phones and tablets from accessing business data 
SIEM integration   Send alerts and logs to SIEM systems for detailed analysis and compliance reporting with exportable security data and reports 

Microsoft Defender for Business is ideal for businesses seeking reliable security without the high cost or complexity of traditional enterprise tools. It is ideal for:

Small to Mid-Sized Businesses (SMBs) 

  • Secure devices, users, and data- whether in-office or remote. 
  • Simplify cybersecurity with an out-of-the-box solution. 

Growing Teams and Remote Resources: 

  • Provide consistent protection across laptops, desktops, and mobile devices. 
  • Keep remote and hybrid employees secure from phishing and malware. 

IT Managers and Admins: 

  • Centralised threat response and management of policies across all endpoints. 
  • Proactive alerts and auto-remediation to save time and resources. 

Are you looking for more practical information on Microsoft Defender for Office 365? We are just a call away.

Meghana

Content Strategist & Blogger
Meghana is a digital marketer with over 8 years of experience helping brands grow through SEO and storytelling. She writes about marketing trends, productivity, and the future of work. When she’s not writing, she enjoys hiking and photography.

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